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Reserve concomitant prescribing for individuals for whom substitute treatment method solutions are inadequate; Restrict dosages and durations for the least needed; and observe sufferers for indications and indications of respiratory depression and sedation.
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ultra-immediate metabolism (break down with the drug in the body for elimination) of tramadol as well as other threat variables for life-threatening respiratory despair in kids (some situations happened right after tonsillectomy or removal of adenoids)
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Many of the noted instances followed surgery to eliminate the tonsils and/or adenoids. In at least one scenario, the child experienced proof of quickly breaking down tramadol inside their human body due to an alteration in enzymes called CYP2D6.